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Support DrugsData Should the public have access to independent analysis of the products they consume?
This was ground under an equal volume of MeOH, producing lemon-yellow crystals of 1- 4-methoxyphenyl nitropropene. Recently, the ethoxy homologue, 4-EA, appeared on the streets of Canada. The meta-compound, 3-MA, has been metabolically explored in man, but no central effects were noted at a 50 milligram dose 2x25 milligrams, separated by three hours. All rights reserved.
I was without any residue by early evening after 5 hours. There appears to be no report of any human trial of 2-MA. The amphetamine metabolite, 4-hydroxyamphetamine hydrochloride 4-HAwas prepared by heating 5. When the daily load gets up around one or two hundred milligrams, Pka subject can become quite psychotic.
The dosage, again, was not reported. The vast majority of analyses of over-the-counter, prescription, and recreational drugs are performed in secret with no independent oversite or eowid. By using this site you agree not to publish or analysis of our data without written permission from Erowid Center. Recrystallization from 4 volumes MeOH did not improve the mp.
The question was asked: might the chronic amphetamine user be methylating his endogenously produced 4-hydroxyamphet-amine to produce 4-methoxyamphetamine 4-MAand maybe this erowidd the agent that promotes the psychosis? After the addition was complete, reflux was continued for 48 h.
Pass drug test erowid
Their synthesis is straightforward, in imitation of that for 4-MA above. After recrystal-lization from aqueous EtOH, the product weighed 3.
To address this question, several studies were done with normal subjects, about 20 years ago, to see if 4-MA might produce a psychotic state it didn't at the highest levels tried, 75 milligrams and to see if it was excreted to Pam extent unchanged in the urines of these normal subjects it was seen even at the lowest dosage tried, 10 milligrams. A major metabolites of amphetamine is 4-hydroxyamphetamine, from oxidation at the 4-position.
DrugsData is a project of Erowid Center. Support DrugsData Should the public have access to independent analysis of the products they consume? I had a feeling of druggedness, almost an alcohol-like intoxication, and I never was really high in the psychedelic sense. On the tragic side, a few years later, 4-MA became widely distributed in both the US as the sulfate salt and in Canada as the hydrochlorideperhaps in-spired by some studies in rats that had reported that it was second only to LSD in potency as a hallucinogen.
An excellent alternate synthesis with a comparable yield involved letting a solution of equimolar amounts of the aldehyde and nitro-ethane and a tenth mole of n-amylamine stand in the dark at room temperature for a couple of weeks. A total erosid 3. Two comments are warranted concerning 4-MA, one of scientific interest, and the other about a social tragedy. The product spontaneously crystal-lized, and could be recrystallized from MeOH.
I could find no record of a typical street dosage, but comments collected in association with the deaths implied that the ingested quantites were in the hundreds of milligrams. The several deaths that occurred probably followed overdose, and it was clear that 4-MA was involved as it had been isolated from both urine and tissue during post mortems.
And since the administration of up to milligrams of amphetamine produced no eroqid 4-MA in the urine, this theory of psychotomimesis is not valid. This aqueous phase was extracted with 3x mL CH2Cl2 which provided, after removal of the solvent, These are the allylbenzene estragole or esdragol and the propenyl isomer anethole.
It was promptly illegalized there. It produced excitation and other central effects, it produced adrenergic pressor effects, and it consistently produced measurable quantities of 4-MA in the urine, but it produced no amphetamine-like crazies.
No other historical record, free from politically-controlled agencies, is currently available in North America nor most other parts of the world. I mPa the effects reminiscent of DET, distinct after-images, and some parasthesia.
Matters of substance
The N-methyl homologues of 3-MA and 4-MA are known, and the latter compound is the stuff of a separate entry in this book. There was obtained white crystals of 4-methoxyamphetamine hydrochloride erpwid that weighed, after filtering, Et2O washing and air drying, This was maintained for another hour.
The N-methyl homologue of 2-MA is a commercial adrenergic bronchodilator called Methoxyphenamine, or Orthoxine. It has been used in the prevention of acute asthma attacks in doses of up to milligrams, Pa only slight central stimulation. Their natural sources have been discussed under TMA. It has been long known that with chronic amphetamine usage there is the generation of tolerance, which encourages ever-increasing doses to be used.